serC [2017-8-11 16:0:3]

3-phosphoserine aminotransferase

locus: BSU10020

pI: 5.52

mw: 39.98 kDa

protein length: 359 aa

gene length: 1077 bp

function: biosynthesis of serine

product: 3-phosphoserine aminotransferase

essential: no

ec: 2.6.1.52

synonyms: yhaF

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.8|Biosynthesis/ acquisition of serine/ glycine/ alanine]

Gene

Coordinates: 1,075,289 → 1,076,368

The protein

Catalyzed reaction/ biological activity

• O-phospho-L-serine 2-oxoglutarate = 3-phosphonooxypyruvate L-glutamate (according to Swiss-Prot)

Protein family

• SerC subfamily (according to Swiss-Prot)

Structure

• [PDB|1W23] (from ''Bacillus alcalophilus'', 59% identity) [Pubmed|15608117]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

additional information

• belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

Expression and Regulation

Operons

• genes: [gene|E7ED2FB756B47A0F2C73E42E4168D16F20BD7B1B|serC]-[gene|97573C2D4FD8BE6B4C749C0644D053C9A0CBFFF3|trpP]
  description: [Pubmed|22383849]

Biological materials

Mutant

• MGNA-A685 (serC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/685 NBRP B. subtilis, Japan]
• 1A621 ( ''serC''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A621&Search=1A621 BGSC]

References

• 15378759,15608117